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Trimethyltin Increases Intracellular Ca2+ Via L-Type Voltage-Gated Calcium Channels and Promotes Inflammatory Phenotype in Rat Astrocytes In Vitro.

Molecular neurobiology - 1 Apr 2021

Dragić Milorad, Milićević Katarina, Adžić Marija, Stevanović Ivana, Ninković Milica, Grković Ivana, Andjus Pavle, Nedeljković Nadežda

Abstract excerpt

Astrocytes are the first responders to noxious stimuli by undergoing cellular and functional transition referred as reactive gliosis. Every acute or chronic disorder is accompanied by reactive gliosis, which could be categorized as detrimental (A1) of beneficial (A2) for nervous tissue. Another signature of pathological astrocyte activation is disturbed Ca2+ homeostasis, a common denominator of neurodegenerative...

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PMID: 33394334
DOI: 10.1007/s12035-020-02273-x

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