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Article

Pathogenic Tau Causes a Toxic Depletion of Nuclear Calcium

1 Jul 2020

Abstract excerpt

Synaptic activity-induced calcium (Ca 2+ ) influx and subsequent propagation into the nucleus is a major way in which synapses communicate with the nucleus to regulate transcriptional programs important for activity-dependent survival and memory formation. Nuclear Ca 2+ shapes the transcriptome by regulating cyclic AMP (cAMP) response element-binding protein (CREB). Here, we utilize a Drosophila model of...

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PMID: 32668249
DOI: 10.1016/j.celrep.2020.107900

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