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Article

Intracellular Ca 2+ stores control in vivo neuronal hyperactivity in a mouse model of Alzheimer’s disease

22 Jan 2018

Abstract excerpt

Significance Although both patients with Alzheimer’s disease (AD) and mouse models of the disease suffer from a profound neuronal hyperactivity mediating an impairment of memory and cognition, the underlying mechanisms remain elusive. Here, we show that neuronal hyperactivity is a hallmark of healthy aging but is further aggravated by AD-related mutations in presenilin 1 protein. AD-mediated enhancement of...

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PMID: 29358403
DOI: 10.1073/pnas.1714409115

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