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Article

Functional Genetics to Understand the Etiology of Autoimmunity.

Genes - 24 Feb 2023

Hatano Hiroaki, Ishigaki Kazuyoshi

Abstract excerpt

Common variants strongly influence the risk of human autoimmunity. Two categories of variants contribute substantially to the risk: (i) coding variants of HLA genes and (ii) non-coding variants at the non-HLA loci. We recently developed a novel analytic pipeline of T cell receptor (TCR) repertoire to understand how HLA coding variants influence the risk. We identified that the risk variants increase the frequency...

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Identifiers

PMID: 36980846
DOI: 10.3390/genes14030572
PMCID: PMC10048754

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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