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Functional Genetics to Understand the Etiology of Autoimmunity.

Genes - 24 Feb 2023

Hatano Hiroaki, Ishigaki Kazuyoshi

Abstract excerpt

Common variants strongly influence the risk of human autoimmunity. Two categories of variants contribute substantially to the risk: (i) coding variants of HLA genes and (ii) non-coding variants at the non-HLA loci. We recently developed a novel analytic pipeline of T cell receptor (TCR) repertoire to understand how HLA coding variants influence the risk. We identified that the risk variants increase the frequency...

Topics

Humans
Genetic Predisposition to Disease
Autoimmunity
Quantitative Trait Loci
Gene Expression
RNA Splicing

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 36980846
DOI: 10.3390/genes14030572
PMCID: PMC10048754

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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