Article

Discordant effects of <i>ex-vivo</i> JAK inhibition on inflammatory responses in colonic compared to ileal mucosa

2024-01-20

Abstract excerpt

<h4>Background & aims</h4> Janus kinase (JAK) inhibitors modulating JAK-STAT (signal transducers and activators of transcription) signaling pathway, are used for the treatment of patients with inflammatory bowel diseases (IBD). We aimed to identify the molecular effects of JAK inhibition in the human intestinal mucosa, considering the IBD location and phenotype. <h4>Methods</h4> Colonic and ileal explants from p...

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Literature Corpus work: adc2e4f1-76c1-5e0c-abbf-64c15ce444a0
DOI: 10.1101/2024.01.18.576013

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