Article

Understanding the mechanisms underlying the lack of response to Janus kinase inhibition in ulcerative colitis

2024-10-17

Abstract excerpt

<h4>ABSTRACT</h4> Ulcerative colitis (UC) is a chronic inflammatory disease of the colon. About one-third of UC patients failed to respond to available drugs, including tofacitinib, a broad Janus kinase (JAK) inhibitor. However, the mechanisms underlying patient response or resistance to oral JAK inhibitors remain unknown. To elucidate the molecular and cellular pathways activated by tofacitinib in responder and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 28467535-c7e9-5545-9301-21cbf49658e6
DOI: 10.1101/2024.10.17.618410

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Understanding the mechanisms underlying the lack of response to Janus kinase inhibition in ulcerative colitisDOI 10.1101/2024.10.17.618410Read

The Cell-Specific Effects of JAK1 Inhibitors in Ulcerative ColitisSemantic proximity Read

High-dimensional single-cell analysis identifies cellular signatures associated with response to vedolizumab therapy in ulcerative colitisSemantic proximity Read

A JAK-STAT-activated myeloid hub at ulceration sites underlies resistance to anti-TNF therapy in Crohn’s diseaseSemantic proximity Read

Tofacitinib uptake by patient-derived intestinal organoids predicts individual clinical responsivenessSemantic proximity Read

The Clinical Response of Upadacitinib and Risankizumab is Associated with Reduced Inflammatory Bowel Disease Anti-TNFα Inadequate Response MechanismsSemantic proximity Read

JAK/STAT signaling promotes the emergence of unique cell states in ulcerative colitisSemantic proximity Read

Discordant effects of <i>ex-vivo</i> JAK inhibition on inflammatory responses in colonic compared to ileal mucosaSemantic proximity Read

Ulcerative colitis immune cell landscapes and differentially expressed gene signatures determine novel regulators and predict clinical response to biologic therapySemantic proximity Read

Differential regulation of JAK/STAT-signaling in patients with ulcerative colitis and Crohn’s diseaseSemantic proximity Read

A longitudinal single-cell therapeutic atlas of anti-tumour necrosis factor treatment in inflammatory bowel diseaseSemantic proximity Read

Lamina Propria Phagocyte Profiling Reveals Targetable Signaling Pathways in Refractory Inflammatory Bowel DiseaseSemantic proximity Read

TWEAK is increased in ulcerative colitis and contributes to fibroblast-mediated monocyte activation via heterologous non-canonical NF-kB/STAT3 signallingSemantic proximity Read