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Article

The Cell-Specific Effects of JAK1 Inhibitors in Ulcerative Colitis

18 Jan 2025

Abstract excerpt

JAK1 inhibitors have become an important addition to the therapeutic options for ulcerative colitis (UC), targeting key inflammatory pathways mediated by cytokines such as the IL-6 family, interferons, IL-2 family, IL-10 family, and G-CSF. However, not all patients respond equally, and chronic inflammation persists in a subset of individuals. The variability in treatment response may reflect the heterogeneity of...

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PMID: 39860613
DOI: 10.3390/jcm14020608

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