Article

Intestinal receptor of SARS-CoV-2 in inflamed IBD tissue is downregulated by HNF4A in ileum and upregulated by interferon regulating factors in colon

2020-06-24

Abstract excerpt

<h4>ABSTRACT</h4> Patients with IBD are considered immunosuppressed, but do not seem more vulnerable for COVID-19. Nevertheless, intestinal inflammation has shown an important risk factor for SARS-CoV-2 infection and prognosis. Therefore, we investigated the effect of intestinal inflammation on the viral intestinal entry mechanisms, including ACE2 , in IBD. We collected (un)inflamed mucosal biopsies from CD (n=...

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Literature Corpus work: d7d8ef79-4b6c-557d-b25f-367f4b0e1978
DOI: 10.1101/2020.06.24.169383

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