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Article

Differential regulation of JAK/STAT-signaling in patients with ulcerative colitis and Crohn’s disease

28 Jul 2020

Abstract excerpt

In 2018, the pan-Janus kinase (JAK) inhibitor tofacitinib was launched for the treatment of ulcerative colitis (UC). Although tofacitinib has proven efficacious in patients with active UC, it failed in patients with Crohn's disease (CD). This finding strongly hints at a different contribution of JAK signaling in both entities. Here, we review the current knowledge on the interplay between the JAK/signal...

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PMID: 32821070
DOI: 10.3748/wjg.v26.i28.4055

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