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Werner syndrome: molecular insights into the relationships between defective DNA metabolism, genomic instability, cancer and aging.

Frontiers in bioscience : a journal and virtual library - 1 Sept 2006

Orren David K

Abstract excerpt

Werner syndrome is a segmental progeroid disease characterized by increased cancer and acceleration of specific age-related phenotypes, due to loss of a protein known as WRN. Extensive research over the last decade has revealed much about WRN biochemistry and the etiology of Werner syndrome. WRN possesses multiple DNA-dependent enzymatic activities (ATPase, helicase, exonuclease, and strand annealing) and...

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Source

Identifiers

PMID: 16720342
DOI: 10.2741/1999

Genes

WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Werner syndrome: molecular insights into the relationships between defective DNA metabolism, genomic instability, cancer and aging.PMID 16720342Read ↗

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WRN Mutation Update: Mutation Spectrum, Patient Registries, and Translational Prospects.Semantic proximity Read ↗

Werner Syndrome, aging and cancer.Semantic proximity Read ↗

Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process.Semantic proximity Read ↗

Roles of the Werner syndrome protein in pathways required for maintenance of genome stability.Semantic proximity Read ↗

Research on Werner Syndrome: Trends from Past to Present and Future ProspectsSemantic proximity Read ↗

Crosstalk among DNA Damage, Mitochondrial Dysfunction, Impaired Mitophagy, Stem Cell Attrition, and Senescence in the Accelerated Ageing Disorder Werner SyndromeSemantic proximity Read ↗

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The Werner's Syndrome RecQ helicase/exonuclease at the nexus of cancer and aging.Semantic proximity Read ↗

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