Werner syndrome: molecular insights into the relationships between defective DNA metabolism, genomic instability, cancer and aging.

doi:10.2741/1999

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Article

Werner syndrome: molecular insights into the relationships between defective DNA metabolism, genomic instability, cancer and aging.

Frontiers in bioscience : a journal and virtual library - 1 Sept 2006

Orren David K

Abstract excerpt

Werner syndrome is a segmental progeroid disease characterized by increased cancer and acceleration of specific age-related phenotypes, due to loss of a protein known as WRN. Extensive research over the last decade has revealed much about WRN biochemistry and the etiology of Werner syndrome. WRN possesses multiple DNA-dependent enzymatic activities (ATPase, helicase, exonuclease, and strand annealing) and...

Topics

Adenosine Triphosphatases
Aging
DNA
DNA Damage
DNA Helicases
DNA Repair
DNA Replication
Genomic Instability
Humans
Neoplasms
Phenotype
Telomere
Werner Syndrome

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PMID: 16720342
DOI: 10.2741/1999

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