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Plasma Proteomic Analysis of <i>APOE</i> ε4 Homozygotes Identifies Preclinical Alzheimer’s Disease Alterations Potentially Modulated by Semaglutide

2026-02-17

Abstract excerpt

Individuals who carry two copies of the apolipoprotein E ε4 ( APOE ε4) allele are at high risk of developing Alzheimer’s disease (AD), yet the effects of APOE ε4 homozygosity on biological pathways related to AD over the lifespan are unknown. Here we analyzed the plasma proteomes of APOE ε4/ε4 individuals with and without AD-related cognitive impairment ( n =413) and compared them to the proteomes of cognitive...

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Literature Corpus work
1d4fc964-41b5-5ab9-a1ca-cf4deff0021b
DOI
10.64898/2026.02.14.26346321
Open publication

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Plasma Proteomic Analysis of <i>APOE</i> ε4 Homozygotes Identifies Preclinical Alzheimer’s Disease Alterations Potentially Modulated by SemaglutideDOI 10.64898/2026.02.14.26346321
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