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Article

MYC Induces Immunotherapy and IFNγ Resistance Through Downregulation of JAK2

18 Apr 2023

Abstract excerpt

Immunotherapy has revolutionized the treatment of advanced melanoma. Because the pathways mediating resistance to immunotherapy are largely unknown, we conducted transcriptome profiling of preimmunotherapy tumor biopsies from patients with melanoma that received PD-1 blockade or adoptive cell therapy with tumor-infiltrating lymphocytes. We identified two melanoma-intrinsic, mutually exclusive gene programs, which...

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PMID: 37074069
DOI: 10.1158/2326-6066.cir-22-0184

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