Article

MYC Overexpression Drives Immune Evasion in Human Cancer that is Reversible Through Restoration of Pro-Inflammatory Macrophages

2022-05-13

Abstract excerpt

<h4>ABSTRACT</h4> Cancers evade immune surveillance that in some, but not in many, cases can be reversed through immune checkpoint therapy. Here we report that the MYC oncogene suppresses immune surveillance, activates immune checkpoint expression, and predicts responsiveness to immune checkpoint inhibition. First, when MYC is genomically amplified and overexpressed in 33 different human cancers, this increases i...

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Literature Corpus work: ad49a3a4-95c7-5732-8d11-30c33ea21ab5
DOI: 10.1101/2022.05.13.491873

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