Article

Combinatorial Immunotherapies Overcome MYC-Driven Immune Evasion

2021-05-08

Abstract excerpt

For many human cancers, including triple negative breast cancer (TNBC), a modest number of patients benefit from immune checkpoint inhibitors, and few experience cancer remission 1 . Expression of programed death-ligand 1 (PD-L1), tumor immune infiltration, or tumor mutation burden have been widely investigated for predicting cancer immunotherapy response 1-5 . Whether specific oncogenes diminish response to imm...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 546bb9d6-d2af-5e5b-9e42-083b1b1a1508
DOI: 10.1101/2021.05.07.442684

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Combinatorial Immunotherapies Overcome MYC-Driven Immune EvasionDOI 10.1101/2021.05.07.442684Read

MYC promotes immune-suppression in TNBC via inhibition of IFN signalingSemantic proximity Read

MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signalingSemantic proximity Read

MYC Overexpression Drives Immune Evasion in Human Cancer that is Reversible Through Restoration of Pro-Inflammatory MacrophagesSemantic proximity Read

Anti-CSF-1R therapy with combined immuno- chemotherapy coordinate an adaptive immune response to eliminate macrophage enriched Triple Negative Breast CancersSemantic proximity Read

Type-I interferon signaling is essential for robust metronomic chemo-immunogenic tumor regression in murine triple-negative breast cancerSemantic proximity Read

CBL0137 and NKG2A blockade: a novel immuno-oncology combination therapy for Myc-overexpressing triple-negative breast cancersSemantic proximity Read

Murine models for triple-negative breast cancer with differential responsiveness to immunotherapySemantic proximity Read

Combined immune checkpoint blockade as a therapeutic strategy for BRCA1-mutated breast cancer.Semantic proximity Read

Multidimensional Molecular Profiling of Metastatic Triple-Negative Breast Cancer and Immune Checkpoint Inhibitor Benefit.Semantic proximity Read

DNA barcoding reveals ongoing immunoediting of clonal cancer populations during metastatic progression and in response to immunotherapySemantic proximity Read

Breast cancer progression and metastasis to lymph nodes reveals cancer cell plasticity and MHC class II-mediated immune regulationSemantic proximity Read

Maximizing the Anti-tumor Potential of Immune Checkpoint Blockade through Modulation of Myeloid-specific CXCL16 and STAT1 SignalingSemantic proximity Read