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Article

MYC controls STING levels to downregulate inflammatory signaling in breast cancer cells upon DNA damage

29 Apr 2025

Abstract excerpt

Amplification of the MYC proto-oncogene is frequently observed in various cancer types, including triple-negative breast cancer (TNBC). Emerging evidence suggests that suppression of local antitumor immune responses by MYC, at least in part, explains the tumor-promoting effects of MYC. Specifically, MYC upregulation was demonstrated to suppress the tumor-cell intrinsic activation of a type I interferon response...

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PMID: 40311680
DOI: 10.1016/j.jbc.2025.108560

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