Article

CBL0137 and NKG2A blockade: a novel immuno-oncology combination therapy for Myc-overexpressing triple-negative breast cancers

2024-02-20

Abstract excerpt

<title>Abstract</title> <p>The <italic>MYC</italic> proto-oncogene is upregulated in > 60% of triple-negative breast cancers (TNBCs), it can directly promote tumor cell proliferation and its overexpression negatively regulates anti-tumor immune responses. For all these reasons, <italic>MYC</italic> has long been considered as a compelling therapeutic target. However, pharmacological inhibition of MYC function has...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 03d4bb93-e99f-5181-af8a-82715aa9d59a
DOI: 10.21203/rs.3.rs-3957241/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CBL0137 and NKG2A blockade: a novel immuno-oncology combination therapy for Myc-overexpressing triple-negative breast cancersDOI 10.21203/rs.3.rs-3957241/v1Read

c-Myc-targeted therapy in breast cancer: A review of fundamentals and pharmacological InsightsSemantic proximity Read

MYC promotes immune-suppression in TNBC via inhibition of IFN signalingSemantic proximity Read

Inhibition of CDK4 as a potential therapy for natural killer cell lymphoma with MYC overexpressionSemantic proximity Read

Advances in immunotherapy for triple-negative breast cancerSemantic proximity Read

Combinatorial Immunotherapies Overcome MYC-Driven Immune EvasionSemantic proximity Read

MYCN Drives a Tumor Immunosuppressive Environment Which Impacts Survival in NeuroblastomaSemantic proximity Read

MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signalingSemantic proximity Read

Anti-CSF-1R therapy with combined immuno- chemotherapy coordinate an adaptive immune response to eliminate macrophage enriched Triple Negative Breast CancersSemantic proximity Read

MERTK inhibition cooperates with immunomodulatory cyclophosphamide to induce CXCL9⁺ monocyte-macrophage programming and durable anti-tumor immunity in triple negative breast cancerSemantic proximity Read

CHA1: A New Combinatorial Therapy That Reciprocally Regulates Wnt and JAK/STAT/Interferon Signaling to Re-program Breast Tumors and the Tumor-Resident LandscapeSemantic proximity Read

Cyclin-Dependent Kinase Inhibitors Function as Potential Immune Regulators via Inducing Pyroptosis in Triple Negative Breast CancerSemantic proximity Read

MYC Overexpression Drives Immune Evasion in Human Cancer that is Reversible Through Restoration of Pro-Inflammatory MacrophagesSemantic proximity Read