Article

Zinc Differentially Modulates Tau Aggregation, Fibril Morphology, and Prion-like Seeding in a Construct-Dependent Manner

2026-07-02

Abstract excerpt

<h4>ABSTRACT</h4> The role of tau fibril structure in seeding and propagation of aggregation remains a central unresolved question in tauopathy biology. While non-proteinaceous cofactors are increasingly observed in patient-derived tau filaments, whether they actively determine fibril structure and function is not well understood. Here, we show that zinc, a divalent cation dysregulated in Alzheimer’s disease (AD)...

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Literature Corpus work: 89d50148-c650-502a-9a41-d989610a827e
DOI: 10.64898/2026.07.01.735859

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