Article

Classification of Tauopathies from Human Brain Homogenates through Salt-Modulated Tau Amplification

2025-08-07

Abstract excerpt

Tauopathies are a heterogeneous group of neurodegenerative disorders characterised by the aggregation of the microtubule-associated protein tau in the brain. Recent advances in cryo-electron microscopy have revealed that tau aggregates adopt disease-specific structural conformations. However, translating these findings into practical diagnostic tools remains a challenge. We developed a salt-modulated real-time qua...

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Literature Corpus work: 49da987b-db11-5d1c-85cb-04606ed60593
DOI: 10.1101/2025.08.05.25331458

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