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Article

Water-directed pinning is key to tau prion formation.

Proceedings of the National Academy of Sciences of the United States of America - 6 May 2025

Vigers Michael P, Lobo Samuel, Najafi Saeed, Dubose Austin, Tsay Karen, Ganguly Pritam, Longhini Andrew P, Jin Yingying, Buratto Steven K, Kosik Kenneth S, Shell M Scott, Shea Joan-Emma, Han Songi

Abstract excerpt

Tau forms fibrillar aggregates that are pathological hallmarks of a family of neurodegenerative diseases known as tauopathies. The synthetic replication of disease-specific fibril structures is a critical gap for developing diagnostic and therapeutic tools. This study debuts a strategy of identifying a critical and minimal folding motif in fibrils characteristic of tauopathies and generating seeding-competent...

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Identifiers

PMID: 40294272
DOI: 10.1073/pnas.2421391122
PMCID: PMC12067210

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