Article

BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes

2017-08-07

Abstract excerpt

Bloom syndrome is a cancer predisposition disorder caused by mutations in the BLM helicase gene. Cells from persons with Bloom syndrome exhibit striking genomic instability characterized by excessive sister chromatid exchange events (SCEs). We applied single-cell DNA template strand-sequencing (Strand-seq) to map the genomic locations of SCEs at a resolution that is orders of magnitude better than was previously...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 232e5a07-4324-5663-ad67-6aced76c2f62
DOI: 10.1101/173252

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genesDOI 10.1101/173252Read

G-quadruplexes regulate chromatin accessibility and gene expression in Bloom SyndromeSemantic proximity Read

The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchangesSemantic proximity Read

RECQ-like helicases Sgs1 and BLM regulate R-loop–associated genome instabilitySemantic proximity Read

Depletion of the bloom syndrome helicase stimulates homology-dependent repair at double-strand breaks in human chromosomes.Semantic proximity Read

Conserved roles of RECQ-like helicases Sgs1 and BLM in preventing R-loop associated genome instabilitySemantic proximity Read

Local G-quadruplexes are not a major determinant of altered gene expression in BLM-deficient cellsSemantic proximity Read

The Bloom's syndrome helicase: keeping cancer at bay.Semantic proximity Read

Single-cell transcription profiles in Bloom syndrome patients link <i>BLM</i> deficiency with altered condensin complex expression signaturesSemantic proximity Read

Genome-wide mapping of helicase-generated ssDNA reveals Hrq1 activity at RNA polymerase III-transcribed genesSemantic proximity Read

An essential DNA strand-exchange activity is conserved in the divergent N-termini of BLM orthologs.Semantic proximity Read

Bloom syndrome and the underlying causes of genetic instability.Semantic proximity Read

A novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cellsSemantic proximity Read