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Local G-quadruplexes are not a major determinant of altered gene expression in BLM-deficient cells

2023-09-08

Abstract excerpt

Mutations in the Blm gene can cause Bloom Syndrome, a genetic disorder characterized by genome instability and cancer predisposition. Blm encodes a helicase which was reported to resolve G-quadruplex DNA structures in vitro . The G-quadruplex resolving activity of the BLM helicase has been previously implicated in altering gene expression. However, the exact mechanisms of how G-quadruplex structures may affect...

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Literature Corpus work
db290f50-f6a5-5622-ad30-e4db3a4310d8
DOI
10.1101/2023.09.08.556664
Open publication

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Local G-quadruplexes are not a major determinant of altered gene expression in BLM-deficient cellsDOI 10.1101/2023.09.08.556664
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