Article

The Role of BAZ2-dependent Chromatin Remodeling in Suppressing G4 DNA Structures and Associated Genomic Instability

2024-12-11

Abstract excerpt

DNA G-quadruplexes (G4s) are secondary structures with significant roles in regulating genome function and stability. Dysregulation of the dynamic formation of G4s is linked to genomic instability and disease, but the underlying mechanisms are not fully understood. In this study, we conducted a screen of chromatin-modifying enzymes and identified nine potential inhibitors of G4 formation, including seven that were...

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Literature Corpus work: 77caaa5e-6107-578e-b2e8-72e568dbcf6b
DOI: 10.1101/2024.12.10.627505

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