Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The toposiomerase IIIalpha-RMI1-RMI2 complex orients human Bloom’s syndrome helicase for efficient disruption of D-loops

3 Feb 2022

Abstract excerpt

Homologous recombination (HR) is a ubiquitous and efficient process that serves the repair of severe forms of DNA damage and the generation of genetic diversity during meiosis. HR can proceed via multiple pathways with different outcomes that may aid or impair genome stability and faithful inheritance, underscoring the importance of HR quality control. Human Bloom's syndrome (BLM, RecQ family) helicase plays...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer therapeutics and mechanisms
Share to DNA Repair Mechanisms
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35115525
DOI: 10.1038/s41467-022-28208-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The toposiomerase IIIalpha-RMI1-RMI2 complex orients human Bloom’s syndrome helicase for efficient disruption of D-loopsPMID 35115525Read ↗

The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchangesSemantic proximity Read ↗

Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability.Semantic proximity Read ↗

The BLM dissolvasome in DNA replication and repair.Semantic proximity Read ↗

Structure and cellular roles of the RMI core complex from the bloom syndrome dissolvasome.Semantic proximity Read ↗

Functions of the Bloom Syndrome Helicase N-terminal Intrinsically Disordered RegionSemantic proximity Read ↗

Multiple functions of the ALT favorite helicase, BLMSemantic proximity Read ↗

Multifaceted role of the Topo IIIα–RMI1-RMI2 complex and DNA2 in the BLM-dependent pathway of DNA break end resectionSemantic proximity Read ↗

Genomic instability and cancer: lessons from analysis of Bloom's syndrome.Semantic proximity Read ↗

BLM-dependent Break-Induced Replication handles DSBs in transcribed chromatin upon impaired RNA:DNA hybrids dissolutionSemantic proximity Read ↗

Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes.Semantic proximity Read ↗

More complexity to the Bloom's syndrome complex.Semantic proximity Read ↗

RECQ5: A Mysterious Helicase at the Interface of DNA Replication and TranscriptionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.