Article

Putative G-quadruplex forming sequence signatures in genes differentially transcribed upon loss of BLM or WRN helicases

2015-01-10

Abstract excerpt

<h4>ABSTRACT</h4> Putative G-quadruplex-forming sequences (PQS) have long been implicated in regulation of DNA replication and transcription, though their actual roles are unknown. To gain insight into potential PQS transcriptional function, we map and analyze PQS motifs in promoters of genes differentially-expressed in Bloom Syndrome (BS) and Werner Syndrome (WS), two human genetic disorders resulting in loss of...

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Literature Corpus work: 254438ed-fdce-5d8d-9cb7-570c92316762
DOI: 10.1101/013664

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