Article

HTT is a repressor of ABL activity required for APP induced axonal growth

2019-06-21

Abstract excerpt

<h4>ABSTRACT</h4> ABL tyrosine kinase activity controls several aspects of development including axon patterning. Amyloid precursor protein (APP) is linked to Alzheimer’s disease and previous work established that ABL is a downstream effector in an Appl , the Drosophila App ortholog, signaling pathway which modulates axon outgrowth in the mushroom bodies (MBs), the fly memory center. Here we show that Abl is r...

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Literature Corpus work: ad504ee5-d48c-5e3d-9524-ff4d126b29a5
DOI: 10.1101/679381

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