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Article

Htt is a repressor of Abl activity required for APP-induced axonal growth.

PLoS genetics - 1 Jan 2021

Marquilly Claire, Busto Germain U, Leger Brittany S, Boulanger Ana, Giniger Edward, Walker James A, Fradkin Lee G, Dura Jean-Maurice

Abstract excerpt

Huntington's disease is a progressive autosomal dominant neurodegenerative disorder caused by the expansion of a polyglutamine tract at the N-terminus of a large cytoplasmic protein. The Drosophila huntingtin (htt) gene is widely expressed during all developmental stages from embryos to adults. However, Drosophila htt mutant individuals are viable with no obvious developmental defects. We asked if such defects...

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Identifiers

PMID: 33465062
DOI: 10.1371/journal.pgen.1009287
PMCID: PMC7845969

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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