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Article

<i>Drosophila</i> Amyloid Precursor Protein-Like Is Required for Long-Term Memory

19 Jan 2011

Abstract excerpt

The amyloid precursor protein (APP) plays an important role in Alzheimer's disease (AD), a progressive neurodegenerative pathology that first manifests as a decline of memory. While the main hypothesis for AD pathology centers on the proteolytic processing of APP, very little is known about the physiological function of the APP protein in the adult brain. Likewise, whether APP loss of function contributes to AD...

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PMID: 21248128
DOI: 10.1523/jneurosci.2896-10.2011

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