Article
Molecular Basis of Orb2 Amyloidogenesis and Blockade of Memory Consolidation.
PLoS biology - 1 Jan 2016
Hervás Rubén, Li Liying, Majumdar Amitabha, Fernández-Ramírez María Del Carmen, Unruh Jay R, Slaughter Brian D, Galera-Prat Albert, Santana Elena, Suzuki Mari, Nagai Yoshitaka, Bruix Marta, Casas-Tintó Sergio, Menéndez Margarita, Laurents Douglas V, Si Kausik, Carrión-Vázquez Mariano
Abstract excerpt
Amyloids are ordered protein aggregates that are typically associated with neurodegenerative diseases and cognitive impairment. By contrast, the amyloid-like state of the neuronal RNA binding protein Orb2 in Drosophila was recently implicated in memory consolidation, but it remains unclear what features of this functional amyloid-like protein give rise to such diametrically opposed behaviour. Here, using an array...
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