Article
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP.
Proceedings of the National Academy of Sciences of the United States of America - 5 Oct 2010
Li Hongmei, Wang Baiping, Wang Zilai, Guo Qinxi, Tabuchi Katsuhiko, Hammer Robert E, Südhof Thomas C, Zheng Hui
Abstract excerpt
Amyloidogenic processing of the amyloid precursor protein (APP) generates a large secreted ectodomain fragment (APPsβ), β-amyloid (Aβ) peptides, and an APP intracellular domain (AICD). Whereas Aβ is viewed as critical for Alzheimer's disease pathogenesis, the role of other APP processing products remains enigmatic. Of interest, the AICD has been implicated in transcriptional regulation, and N-terminal cleavage of...
Topics
- Amyloid beta-Protein Precursor
- Animals
- Cells, Cultured
- Gene Expression Profiling
- Gene Expression Regulation
- Genotype
- Glucuronidase
- Humans
- Klotho Proteins
- Mice
- Mice, Knockout
- Microarray Analysis
- Nerve Tissue Proteins