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Integral gene drives for population replacement

1 Jan 2018

Abstract excerpt

A first generation of CRISPR-based gene drives has now been tested in the laboratory in a number of organisms, including malaria vector mosquitoes. Challenges for their use in the area-wide genetic control of vector-borne disease have been identified, including the development of target site resistance, their long-term efficacy in the field, their molecular complexity, and practical and legal limitations for...

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PMID: 30498016
DOI: 10.1242/bio.037762

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