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Article

Elevated 4R-tau in astrocytes from asymptomatic carriers of the MAPT 10+16 intronic mutation.

Journal of cellular and molecular medicine - 1 Feb 2022

Setó-Salvia Núria, Esteras Noemi, de Silva Rohan, de Pablo-Fernandez Eduardo, Arber Charles, Toomey Christina E, Polke James M, Morris Huw R, Rohrer Jonathan D, Abramov Andrey Y, Patani Rickie, Wray Selina, Warner Thomas T

Abstract excerpt

The microtubule-associated protein tau gene (MAPT) 10+16 intronic mutation causes frontotemporal lobar degeneration (FTLD) by increasing expression of four-repeat (4R)-tau isoforms. We investigated the potential role for astrocytes in the pathogenesis of FTLD by studying the expression of 4R-tau. We derived astrocytes and neurons from induced pluripotent stem cells from two asymptomatic 10+16 carriers which,...

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Identifiers

PMID: 34951131
DOI: 10.1111/jcmm.17136
PMCID: PMC8831975

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Elevated 4R-tau in astrocytes from asymptomatic carriers of the MAPT 10+16 intronic mutation.PMID 34951131Read ↗

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