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Article

MAPT Isoforms: Differential Transcriptional Profiles Related to 3R and 4R Splice Variants

7 Jan 2011

Abstract excerpt

Tau aggregation in neurofibrillary tangles is a pathological hallmark in tauopathies including Alzheimer's disease (AD). The predominant aggregation of certain MAPT (tau gene) isoforms, either the 4-repeat (4R tau) or the 3-repeat (3R tau) isoform has been widely described in tauopathies. Alterations of the 4R tau to 3R tau ratio may be a key for tau-related neurodegeneration. To study the biological consequences...

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Identifiers

PMID: 20930284
DOI: 10.3233/jad-2010-101155

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