Cardiac differentiation roadmap for analysis of plasticity and balanced lineage commitment

Abstract excerpt

<h4>ABSTRACT</h4> Stem cell-based models of human heart tissue and cardiac differentiation employ monolayer and 3D organoid cultures with different properties, cell type composition, and maturity. Here we show how cardiac monolayer, embryoid body, and engineered heart tissue trajectories compare in a single-cell roadmap of atrial and ventricular differentiation conditions. Using a multiomic approach and gene-regu...

Topics

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• Cardiac Fibrosis and Remodeling
• Cardiomyopathy and Myosin Studies
• Cardiovascular Function and Risk Factors
• Congenital heart defects research
• Congenital Heart Disease Studies
• Pluripotent Stem Cells Research
• Single-cell and spatial transcriptomics
• Tissue Engineering and Regenerative Medicine

Identifiers and source

Literature Corpus work

cbabc1cd-e665-5635-9a76-4b84d087907a

DOI

10.1101/2024.04.09.588683