Fate of developmental mechanisms of myocardial plasticity in the postnatal heart

Abstract excerpt

<h4>SUMMARY</h4> Whether the heart’s organ-founding, progenitor cell gene regulatory networks (CPC-GRNs) are sustained after birth and can be therapeutically evoked for regeneration in response to disease, remains elusive. Here, we report a spatiotemporally resolved analysis of CPC-GRN deployment dynamics, through the pan-CPC-GRN gene Isl1 . We show that the Isl1-CPC-GRNs that are deployed during early cardiogen...

Topics

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• Cardiac Fibrosis and Remodeling
• Cardiomyopathy and Myosin Studies
• Cardiovascular Function and Risk Factors
• Congenital heart defects research
• Congenital Heart Disease Studies
• Coronary Artery Anomalies
• Single-cell and spatial transcriptomics
• Tissue Engineering and Regenerative Medicine

Identifiers and source

Literature Corpus work

281cd08c-d7aa-5db5-b6ab-21b75e64d30e

DOI

10.1101/842864