GATA4 Is a Direct Transcriptional Activator of <i>Cyclin D2</i> and <i>Cdk4</i> and Is Required for Cardiomyocyte Proliferation in Anterior Heart Field-Derived Myocardium

Abstract excerpt

The anterior heart field (AHF) comprises a population of mesodermal progenitor cells that are added to the nascent linear heart to give rise to the majority of the right ventricle, interventricular septum, and outflow tract in mammals and birds. The zinc finger transcription factor GATA4 functions as an integral member of the cardiac transcription factor network in the derivatives of the AHF. In addition to its...

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