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Article

Gata4 potentiates second heart field proliferation and Hedgehog signaling for cardiac septation

6 Feb 2017

Abstract excerpt

Significance Dominant GATA4 mutations cause congenital heart defects in humans, but the mechanistic basis whereby Gata4 haploinsufficiency causes disease is unknown. We demonstrate that Gata4 is required in a subset of cardiac progenitor cells called the “second heart field” for cardiac septation. Furthermore, we identified two distinct pathways downstream of Gata4 , phosphatase and tensin homolog ( Pten...

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PMID: 28167794
DOI: 10.1073/pnas.1605137114

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