Article

Hormone circuit analysis explains why most HPA drugs fail for mood disorders and predicts the few that work

2024-06-10

Abstract excerpt

Elevated cortisol causes morbidity in chronic stress and mood disorders, including metabolic and cardiovascular diseases. There is therefore interest in developing drugs that lower cortisol by targeting its endocrine pathway, the hypothalamic-pituitary-adrenal (HPA) axis. Several promising HPA-modulating drugs have, however, failed to lower long-term cortisol in mood disorders such as major depressive disorder des...

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Literature Corpus work: acf97c37-1652-5e3d-a29d-8b8f3c49aa86
DOI: 10.1101/2024.06.10.598205

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