Stress and affective disorders: animal models elucidating the molecular basis of neuroendocrine-behavior interactions.

Abstract excerpt

Profound dysfunctions in several neuroendocrine systems have been described in patients suffering from affective disorders such as major depression. In order to elucidate the mechanisms underlying these functional alterations, animal models including mice genetically modified by either direct gene-targeting or by selective breeding approaches have been used exceedingly, revealing valuable insights into...

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