Back to search

Article

Dissection of the corticotroph transcriptome in a mouse model of glucocorticoid-induced suppression of the HPA axis

2020-07-30

Abstract excerpt

<h4>ABSTRACT</h4> Glucocorticoids (GC) are prescribed for periods >3 months to 1-3% of the UK population; 10-50% of these patients develop hypothalamus-pituitary-adrenal (HPA) axis suppression, which may last over 6 months and is associated with morbidity and mortality. Recovery of higher nodes of the axis is necessary for recovery of adrenal function. We developed a mouse model of Dexamethasone (DEX)-induced HPA...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
5e2cb6a5-2848-5125-8e1d-e559264f6843
DOI
10.1101/2020.07.29.227330
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Dissection of the corticotroph transcriptome in a mouse model of glucocorticoid-induced suppression of the HPA axisDOI 10.1101/2020.07.29.227330
Long-term, Dynamic Remodelling of the Corticotroph Transcriptome and Excitability After a Period of Chronic StressSemantic proximity
Primary Generalized Glucocorticoid Resistance and Hypersensitivity Syndromes: A 2021 UpdateSemantic proximity
Single cell transcriptomic analysis of the adult mouse pituitary reveals a novel multi-hormone cell cluster and physiologic demand-induced lineage plasticitySemantic proximity
Suppressive action of nesfatin-1 and nesfatin-1-like peptide on cortisol synthesis in adrenal cortex cellsSemantic proximity
Insights into glucocorticoid responses derived from omics studiesSemantic proximity
Absent, but not glucocorticoid-modulated, corticotropin-releasing hormone (Crh) regulates anxiety-like behaviors in miceSemantic proximity
A cross-tissue transcriptomic approach decodes glucocorticoid receptor-dependent links to human metabolic phenotypesSemantic proximity
Genetically Engineered Human Pituitary Corticotroph Tumor Organoids Exhibit Divergent Responses To Glucocorticoid Receptor ModulatorsSemantic proximity
Single-cell molecular profiling of all three components of the HPA axis reveals adrenal ABCB1 as a regulator of stress adaptationSemantic proximity
Glucocorticoids, their uses, sexual dimorphisms, and diseases: new concepts, mechanisms, and discoveriesSemantic proximity
HPA axis dysregulation in mice overexpressing corticotropin releasing hormone.Semantic proximity
Elimination of Foxo triplets following glucocorticoid incubation dampened metabolic stress and enhanced anti-viral response targets based on transcriptomic analysisSemantic proximity
Select a neighboring publication to make it the new centre.