Article

Increased Cortisol and Antiglucocorticoid Therapy in Mood Disorders: The Hippocampus as a Potential Drug Target

2024-01-19

Abstract excerpt

The pathophysiology of many mood disorders is closely related with abnormal stress response associated with the dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis and cortisol overproduction. The hippocampus, key structure of the limbic system responsible for both cognitive and emotional spheres, is selectively vulnerable to excess of glucocorticoids (GCs) inducing neuroinflammation and neurodegeneration...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ac3114ce-d084-5cb5-b713-3cf79b714d46
DOI: 10.20944/preprints202401.1448.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Increased Cortisol and Antiglucocorticoid Therapy in Mood Disorders: The Hippocampus as a Potential Drug TargetDOI 10.20944/preprints202401.1448.v1Read

Hippocampal Volume Changes in Patients with Mood Disorders: A Systematic Review of MRI StudiesSemantic proximity Read

A translational approach to clinical practice via stress-responsive glucocorticoid receptor signalingSemantic proximity Read

Hormones and the Stressed BrainSemantic proximity Read

Stress and Depression: a Crucial Role of the Mineralocorticoid Receptor.Semantic proximity Read

A General Introduction to Glucocorticoid BiologySemantic proximity Read

Psychological stress and aging: role of glucocorticoids (GCs).Semantic proximity Read

Mechanisms of Neuroimmune Interactions in Stress Physiology, Health Implications, and Emerging Therapeutic Targets.Semantic proximity Read

Targeting glucocorticoid receptor signaling pathway for treatment of stress-related brain disordersSemantic proximity Read

Glucocorticoids, their uses, sexual dimorphisms, and diseases: new concepts, mechanisms, and discoveriesSemantic proximity Read

Circadian regulation of hippocampal function is disrupted with chronic corticosteroid treatmentSemantic proximity Read

Childhood adversity and allostatic overload of the hypothalamic-pituitary-adrenal axis: a vulnerability model for depressive disorders.Semantic proximity Read

Apelin-13 Upregulates BDNF Against Chronic Stress-induced Depression-like Phenotypes by Ameliorating HPA Axis and Hippocampal Glucocorticoid Receptor Dysfunctions.Semantic proximity Read