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Article

CRH, stress, and major depression: a psychobiological interplay.

Vitamins and hormones - 1 Jan 2004

Claes Stephan J

Abstract excerpt

Major depressive disorder (MDD) is a complex disease and is one of the leading causes of disability in our society. The provoking factors are multiple; acute and chronic psychological stress, severe early trauma experiences, somatic disease, and genetic factors all play a role. This review focuses on hyperdrive of corticotropin-releasing hormone (CRH) as the fundamental neurobiological correlate of MDD. CRH plays...

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Source

Identifiers

PMID: 15196881
DOI: 10.1016/S0083-6729(04)69005-4

Genes

CRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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