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Slow Stress-Load Accumulation Dominates BDNF-Dependent Gain in a Ten-State Computational Model of Stress Biochemistry

2026-07-21

Abstract excerpt

<h4>Background</h4> Acute stress responses are often reversible, whereas sustained stress can produce coordinated disruption across endocrine, metabolic, inflammatory, antioxidant, and neuroplastic pathways. The Tiered Stress Biochemistry Model (TSBM) is a hypothesis-generating ten-state ordinary differential-equation framework linking a stylized cortisol signal to noradrenergic drive, vitamin C, a phenomenologic...

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Literature Corpus work
585ea320-8bc7-5a48-bb14-dfebe32b1990
DOI
10.64898/2026.07.15.738784
Open publication

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