Article
Association of endogenous hormones with major depressive disorder phenotype: A systematic review and meta-analysis of drug-free case and control cross-sectional study.
Biochemical and biophysical research communications - 31 Dec 2025
Machahary Nitin, Thakran Sarita, Thampi Gayathri, Gangte Niengjolly, Sood Mamta, Kaushik Mahima, Kukreti Ritushree
Abstract excerpt
BACKGROUND: Major Depressive Disorder (MDD) represents a major global health issue with complex and partially characterised biological foundations. In addition to the recognised hypothalamic-pituitary-adrenal (HPA) axis in stress response, there exists evidence for hypothalamic-pituitary-thyroid/gonadal (HPT/G) axis dysregulation in MDD. Addressing the prior research inconsistencies, this meta-analysis provides...
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