Article

Hormonal Dysregulation in Major Depressive Disorder: A Systematic Review

2025-04-27

Abstract excerpt

<p>Background: Major Depressive Disorder (MDD) is a leading cause of global disability, affecting approximately 280 million people worldwide and exhibiting a two- to three‐fold higher prevalence in women (World Health Organization, 2023). Neuroendocrine systems—including the hypothalamic–pituitary–adrenal (HPA), –thyroid (HPT), –gonadal (HPG), metabolic, and somatotropic axes—modulate mood via genomic and rapid no...

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Literature Corpus work: b2e9ccfd-6091-50dd-8270-41932a9cbfe3
DOI: 10.31234/osf.io/y897m_v2

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