Functional and genetic epidemiological characterisation of the FFAR4 (GPR120) p.R270H variant in the Danish population.

doi:10.1136/jmedgenet-2015-103728

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Article

Functional and genetic epidemiological characterisation of the FFAR4 (GPR120) p.R270H variant in the Danish population.

Journal of medical genetics - 1 Sept 2016

Vestmar Marie A, Andersson Ehm A, Christensen Charlotte R, Hauge Maria, Glümer Charlotte, Linneberg Allan, Witte Daniel R, Jørgensen Marit E, Christensen Cramer, Brandslund Ivan, Lauritzen Torsten, Pedersen Oluf, Holst Birgitte, Grarup Niels, Schwartz Thue W, Hansen Torben

Abstract excerpt

BACKGROUND: p.R270H (rs116454156) in the long chain fatty acid 7TM receptor FFAR4 (GPR120) which results in impaired Gαq (Gq) coupled signalling, has been associated with obesity. We aimed to extend the functional in vitro analyses of p.R270H and to investigate the association with obesity and glucose-related traits in the Danish population. METHODS: Surface expression, Gq and Gi coupled signalling as well as...

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PMID: 27068006
DOI: 10.1136/jmedgenet-2015-103728

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FFAR4
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