Article

The CryoEM Structure of Human GPR75: Insights into ECL2-Mediated Activation

2025-07-30

Abstract excerpt

GPR75 is one of the most promising emerging targets for the treatment of obesity and related co-morbidities, as its loss of function directly correlates with a decreased body mass index (BMI) in humans. To date, little is known about the structure and underlying biology of GPR75, which is classified as an orphan GPCR and has low homology to other GPCRs. Here, we describe the cryoEM structure of ICL3-BRIL-fused, un...

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Literature Corpus work: a9dc450d-852f-54bb-bf6b-57083396dc50
DOI: 10.1101/2025.07.30.667585

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