Article

Melanocortin 1 Receptor Activation Protects Against Alpha-Synuclein Pathologies in Models of Parkinson’s Disease

2021-03-13

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Epidemiological studies suggest a link between the melanoma-related pigmentation gene melanocortin 1 receptor ( MC1R ) and risk of Parkinson disease (PD). We previously showed that MC1R signaling can facilitate nigrostriatal dopaminergic neuron survival. The present study investigates the neuroprotective potential of MC1R against neurotoxicity induced by alpha-s...

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Literature Corpus work: b2ad94c0-c38a-51ff-b1df-60cc6079afb0
DOI: 10.21203/rs.3.rs-286792/v1

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