Article

Infiltrating Peripheral Monocyte TREM-1 Mediates Dopaminergic Neuron Injury in Substantia Nigra of Parkinson's Disease Model Mice

2024-04-17

Abstract excerpt

<title>Abstract</title> <p>Background Neuroinflammation is a crucial factor in the pathogenesis of Parkinson's disease (PD). Activated microglia in the central nervous system (CNS) and peripherally infiltrating immune cells contribute to the degeneration of dopaminergic neurons. However, how the peripheral immune system leads to neuron loss and whether blocking this response slows disease progression remain large...

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Literature Corpus work: 77ee5934-9737-5814-9432-2f81e89f8193
DOI: 10.21203/rs.3.rs-4169068/v1

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