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Article

Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson’s disease

23 Feb 2022

Abstract excerpt

BACKGROUND: Epidemiological studies suggest a link between the melanoma-related pigmentation gene melanocortin 1 receptor (MC1R) and risk of Parkinson's disease (PD). We previously showed that MC1R signaling can facilitate nigrostriatal dopaminergic neuron survival. The present study investigates the neuroprotective potential of MC1R against neurotoxicity induced by alpha-synuclein (αSyn), a key player in PD...

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PMID: 35197079
DOI: 10.1186/s13024-022-00520-4

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