Article

Activation of central cannabinoid type 2 receptors, but not on peripheral immune cells, is required for endocannabinoid-mediated neuroprotection in Parkinson´s disease

2024-09-08

Abstract excerpt

<title>Abstract</title> <p>Background Neuroinflammation is a key feature of Parkinson´s disease (PD), a neurodegenerative disease for which there is no cure. The cannabinoid receptor type 2 (CB2R) is expressed by cells of the innate and adaptive immune systems. Inhibition of monoacylglycerol lipase increases the levels of the endocannabinoid 2-arachidonoylglycerol (2-AG), which is neuroprotective in an experimen...

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Literature Corpus work: 1f397c01-e505-55a8-b48b-860b40ac710c
DOI: 10.21203/rs.3.rs-4752464/v1

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